Energia Medical LLC - Blog , ScienceEnergia Medical LLC - Blog , Sciencehttps://www.energiamedical.com/blogs/ScienceWed, 18 Mar 2026 15:55:16 -0700http://zoho.com/sites/<![CDATA[The Science of Mechanotransduction and Vibration Therapy: Clinical Relevance for Podiatrists, Chiropractors, and Physical Therapists]]>https://www.energiamedical.com/blogs/post/Science-of-Mechanotransduction-and-Vibration-Therapy

Introduction

Mechanical forces are central to musculoskeletal health and rehabilitation. Manual therapy, joint mobilization, gait retraining, and progressive exercise loading all rely on the body’s ability to sense and respond to mechanical input. This biologic process, known as mechanotransduction, explains how physical forces applied at the tissue level translate into cellular and molecular responses that drive adaptation.


Vibration therapy represents a controlled mechanical stimulus capable of engaging mechanotransduction pathways across muscle, vascular, and skeletal systems. Increasingly, research shows that both high-energy vibration and low-intensity vibration can influence cellular behavior through distinct but complementary mechanisms. Understanding these pathways allows clinicians to better match vibration parameters to patient tolerance and therapeutic goals.

Mechanotransduction: How Cells Sense Mechanical Forces

Mechanotransduction refers to the conversion of mechanical forces into biochemical signals. Cells detect mechanical input through integrins, stretch-activated ion channels, and the cytoskeleton, which transmits force toward the nucleus and alters gene expression [1–3]. These pathways regulate protein synthesis, inflammatory signaling, mitochondrial activity, and tissue remodeling.


In musculoskeletal tissues, mechanotransduction governs muscle hypertrophy, connective tissue adaptation, angiogenesis, and bone remodeling [1,4,14]. Vibration therapy leverages these same biologic systems but does so using oscillatory forces rather than static or repetitive loading.

Diagram illustrating mechanotransduction from extracellular matrix through integrins and cytoskeleton to the nucleus

How Vibration Becomes a Cellular Signal

Mechanical vibration introduces small, rapid accelerations that cause micro-deformation of muscle fibers, blood vessels, and bone matrix. These forces generate membrane stretch and fluid shear stress, activating mechanosensitive ion channels and intracellular signaling cascades [2–4].


Downstream effects include increased intracellular calcium, activation of MAPK and PI3K/Akt signaling, and changes in gene expression related to nitric oxide production, growth factor release, and bone morphogenetic proteins [2–4,14]. Clinical outcomes depend heavily on vibration dose. Frequency, amplitude, posture, and exposure duration determine whether vibration primarily affects neuromuscular activation, vascular function, or deeper cellular signaling processes [5,7,8].

Nuclear Mechanosensitivity and the Role of the LINC Complex

Beyond membrane-level mechanosensing, the nucleus itself functions as a mechanosensitive organelle. Central to this process is the LINC (Linker of Nucleoskeleton and Cytoskeleton) nuclear complex, which physically connects the cytoskeleton to the nuclear envelope via SUN and nesprin proteins.


The LINC complex enables mechanical forces applied at the cell surface to be transmitted directly to the nucleus, influencing chromatin organization, nuclear stiffness, and transcriptional activity [26]. This mechanism is especially relevant to low-intensity vibration, where mechanical forces may be insufficient to cause visible tissue deformation but are still capable of producing meaningful cellular responses.


Disruption of LINC connectivity impairs mechanosensitive gene expression and reduces osteogenic signaling, while intact LINC complexes enhance nuclear strain transfer and mechanically regulated transcription [26].

Low-Intensity Vibration and Cellular Adaptation

Low-intensity or low-magnitude vibration produces acceleration signals that are well tolerated by older adults and individuals with limited load capacity. Despite minimal perceptible movement, these signals can activate intracellular and nuclear mechanotransduction pathways through the LINC complex.


Low-intensity vibration has been shown to influence mesenchymal stem cell differentiation toward osteogenic rather than adipogenic lineages, maintain cytoskeletal tension and nuclear integrity, and regulate gene expression relevant to bone and muscle health [26]. This helps explain why low-magnitude, high-frequency vibration demonstrates biologic effects despite very small displacement amplitudes.

Neuromuscular Activation and Functional Loading

At higher amplitudes or frequencies, vibration therapy engages neuromuscular pathways through the tonic vibration reflex and altered motor unit recruitment [7,8,20]. Increased electromyographic activity has been demonstrated in lower-limb and trunk musculature, particularly in the 20–40 Hz range [8,20,24].


Physical therapists may integrate vibration into balance training, early strengthening, and gait re-education. Chiropractors may use vibration to enhance proprioception and postural control alongside spinal stabilization strategies. Podiatrists may apply vibration to improve intrinsic foot muscle activation and sensorimotor input in patients with balance deficits or neuropathy.

Circulation and Microvascular Effects

Vibration induces rhythmic muscle contractions and cyclic shear stress on blood vessels, influencing microcirculation and endothelial function. Acute increases in blood flow and muscle oxygenation have been observed during and after vibration exposure [5,13]. Improvements in flow-mediated dilation and endothelial progenitor cell mobilization have also been reported following vibration therapy [10,11,21].


These effects may support tissue healing and metabolic exchange, particularly in populations with compromised microvascular function.

Bone Metabolism and Skeletal Health

Bone is highly mechanosensitive, with osteocytes acting as primary mechanosensors that translate mechanical forces into signals regulating osteoblast and osteoclast activity [14–16,22]. Both high-energy and low-intensity vibration have demonstrated effects on bone signaling pathways.


Low-magnitude vibration may help attenuate bone loss in populations with limited weight-bearing tolerance, including older adults and individuals recovering from prolonged immobilization [17,18,23]. The LINC nuclear complex plays a critical role in these responses by enabling nuclear-level mechanotransduction in bone cells [26].

Bone Remodeling Cycle

Clinical Takeaways for Healthcare Providers

Mechanotransduction explains the biologic basis for vibration therapy across muscle, vascular, and skeletal systems. High-energy vibration primarily enhances neuromuscular activation and proprioception. Low-intensity vibration engages nuclear mechanosensitivity through the LINC complex, influencing cellular behavior with minimal tissue strain. Vibration therapy should complement, not replace, active rehabilitation and progressive loading. Careful patient selection and dosing are essential, particularly in older adults and those with reduced load tolerance.

References 

  1. Dunn SL, Heilig CW, Bao J, et al. Mechanotransduction: Relevance to physical therapist practice—understanding our ability to affect genetic expression through mechanical forces. Phys Ther. 2016;96(5):712–721.
  2. Wang N, Tytell JD, Ingber DE. Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Rev Physiol Biochem Pharmacol. 2017;169:37–82.
  3. Martino F, Perestrelo AR, Vinarský V, Pagliari S, Forte G. Cellular mechanotransduction: from tension to function. Front Physiol. 2018;9:824.
  4. Di X, Wang Y, Han D, et al. Cellular mechanotransduction in health and diseases. Signal Transduct Target Ther. 2023;8(1):152.
  5. Games KE, Sefton JM. Whole-body vibration influences lower extremity circulatory and neurological function. J Athl Train. 2015;50(6):585–593.
  6. Liu C, Sun Y, Wang L, et al. The central mechanotransducer in osteoporosis pathogenesis: Piezo1 and its signaling pathways. Bone Res. 2025;13(1):23.
  7. Yang Z, Li Z, Zhu Q, et al. Effects of different vibration frequencies on muscle strength: a randomized trial of whole-body vibration training. Sci Rep. 2021;11(1):53.
  8. Marín PJ, Santos-Lozano A, Santin-Medeiros F, et al. The effects of whole-body vibration on electromyographic activity and muscle performance. J Strength Cond Res. 2021;35(4):1039–1047.
  9. Yin Y, Mu J, Wang H, et al. Does whole-body vibration training have a positive effect on neuromuscular performance? Front Hum Neurosci. 2023;16:1076665.
  10. Aoyama A, Uematsu A, Shibata K, et al. Acute effects of whole-body vibration training on endothelial function in elderly patients with cardiovascular disease. Int Heart J. 2019;60(4):834–841.
  11. Jawed Y, Braverman J, Hsu JD, et al. Whole-body vibration training increases stem/progenitor cells and skin blood flow in humans. Mil Med. 2020;185(Suppl 1):404–411.
  12. Haffner-Luntzer M, Kovtun A, Lackner I, et al. Effects of low-magnitude high-frequency vibration on bone healing and remodeling. Biochim Biophys Acta Mol Basis Dis. 2018;1864(12):2293–2301.
  13. Steppe L, Neumeyer F, Klein-Nulend J, et al. Influence of low-magnitude high-frequency vibration on bone cells in vitro and in vivo. Front Bioeng Biotechnol. 2020;8:595139.
  14. Cao S, Liu J, Rong Y, et al. The effect of whole-body vibration exercise on bone metabolism and density in postmenopausal women. Medicine (Baltimore). 2021;100(19):e25791.
  15. Wang L, You X, Zhang L, et al. Mechanical regulation of bone remodeling. Bone Res. 2022;10(1):54.
  16. Sun W, Chi S, Li Y, et al. The mechanosensitive ion channel Piezo1 is required for bone formation. Nature. 2019;573:225–229.
  17. Rubin C, Recker R, Cullen DM, et al. Prevention of bone loss in postmenopausal women using low-level whole body vibration. Lancet. 2004;364(9446):1943–1950.
  18. von Stengel S, Kemmler W, Engelke K, et al. Effect of whole-body vibration on neuromuscular and functional performance. J Musculoskelet Neuronal Interact. 2011;11(2):145–155.
  19. Rittweger J. Vibration as an exercise modality. Eur J Appl Physiol. 2010;108(5):877–904.
  20. Ritzmann R, Kramer A, Gollhofer A. The neuromuscular effects of vibration exercise. Eur J Appl Physiol. 2013;113(6):1645–1654.
  21. Maloney-Hinds C, Petrofsky JS, Zimmerman G. The effect of vibration frequency on skin blood flow. Med Sci Monit. 2008;14(5):CR237–CR244.
  22. Li X, Han L, Nookaew I, et al. Stimulation of Piezo1 by mechanical signals promotes bone anabolism. Proc Natl Acad Sci USA. 2019;116(28):14138–14144.
  23. Judex S, Rubin CT. Is bone formation induced by low-level whole body vibration? Exerc Sport Sci Rev. 2010;38(4):191–196.
  24. Saxena H, Filho RF, Raza S, et al. Effect of multi-frequency whole-body vibration on muscle activation. Sensors (Basel). 2020;20(9):2575.
  25. Lau E, Al-Dujaili S, Guenther A, et al. Mechanical loading and endothelial progenitor cell mobilization. Bone. 2010;46(6):1443–1452.
  26. Uzer G, Rubin CT, Rubin J. Cell mechanosensitivity is enabled by the LINC nuclear complex. Curr Mol Biol Rep. 2016;2(1):36–47. 

 

]]>Sun, 28 Dec 2025 13:40:22 -0500<![CDATA[The Importance Of Maintaining Good Circulation And Microcirculation]]>https://www.energiamedical.com/blogs/post/The-Importance-Of-Maintaining-Good-Circulation-And-Microcirculation

According to WebMD.com, "It’s hard to believe, but your body holds about 60,000 miles of blood vessels. Along with your heart and other muscles, they make up your circulatory system. This network of roadways carries blood to every corner of your body." [1] But in order for your blood to flow unrestricted, good circulation and microcirculation are crucial. "Circulation" refers to the flow of blood coursing through your network of blood vessels, while "microcirculation" refers to the flow of blood coursing through your capillaries the smallest blood vessels.

 

Good Circulation and Microcirculation

Good circulation and microcirculation are very important for your health and wellness. Blood full of oxygen, nutrients, and hormones must flow unrestricted to all the cells in your body, including your nerves, tissues, muscles, and vital organs, in order for them to operate properly. And carbon dioxide and waste products must be adequately collected and removed from your cells through the capillaries.


Dangers of Poor Circulation

When circulation and microcirculation are poor because blood flow is restricted (by plaque buildup in the arteries, for example), your cells cannot receive all of the oxygen, nutrients, and hormones that they require for proper functioning increasing your risk of disease. Microcirculation rarefaction has been associated with cardiovascular and metabolic diseases, including hypertension, diabetes, obesity and metabolic syndrome. In addition, "the rarefaction of microcirculation in capillary beds is related to target organ damage”. [2] Vital organs such as the heart, kidneys, and brain can be harmed by poor circulation and microcirculation.

 

Ways to Maintain Good Circulation & Microcirculation

What can you do to increase and maintain good circulation and microcirculation? This can be accomplished in several ways: exercise; diet; supplements; medications; and massage therapy. WebMD.com also recommends: controlling blood pressure; staying hydrated; standing at a desk rather than sitting; yoga; warm baths; and lots of fruits and vegetables. [3] But perhaps the easiest way to increase and maintain good circulation and microcirculation iswith Red Light/Infrared Therapy!

 

Red/Infrared Light Therapy Increases Circulation

A non-invasive, easy, and highly effective way to increase circulation and microcirculation for better health is by using Red/Infrared Light Therapy. Red/Infrared Light Therapy is also known as (phototherapy) and (photobiomodulation) (PBM).  It can be defined as, "the use of red and near-infrared light to stimulate healing, relieve pain, and reduce inflammation." [4] Red Light and Infrared Light Therapy induces a wide range of beneficial effects on the body, including increased circulation. "The beneficial outcomes of phototherapy for the treatment of acute and chronic musculoskeletal disorders include pain control, enhanced blood circulation, and improved tissue repair." [5] Higher quality, professional-level Red Light and Infrared Light Therapy systems (such as devices sold by Energia Medical) have been granted FDA clearance for increasing circulation, and also for relieving pain; relaxing muscles, relieving muscle spasms, and relieving the aches and stiffness caused by arthritis.

 

How Red/Infrared Light Therapy Works

Light Therapy systems are simple and easy to use.When a Light Therapy pad is placed on the body, photons of light are released which induce cascades of beneficial biochemical processes within the cells. "Radiation of tissue with light causes an increase in mitochondrial products such as ATP, NADH, protein, and RNA” [6]  Also released is nitric oxide (NO), known as the body’s natural vasodilator, which increases circulation so that blood teeming with oxygen and nutrients can now flow more freely into that local area. The increase in circulation accelerates the body’s natural healing processes, leading to better health and wellness. "This vasodilation increases the availability of oxygen to treated cells, and also allows for greater traffic of immune cells into tissue. These two effects contribute to accelerated healing."[7]

 

Light Therapy Benefits the Entire Body

Light Therapy can benefit circulation and microcirculation in virtually every part of the body. Just place the light therapy pad over any area where an increase in circulation is needed. And increased circulation leads to pain relief and healing support wherever the Light Therapy pad is placed. A typical therapy session lasts for twenty minutes, and can be administered as needed to improve and then maintain good circulation and microcirculation.

 

Studies Prove Red Light/Infrared Therapy Supports Circulation and Microcirculation

Peer-reviewed scientific studies on PubMedvprove that Red Light/Infrared Light Therapy is effective for improving circulation and microcirculation. Here are two studies:

 

  • A 2007 human study of the effects of visible light and near-infrared light on skin microcirculation and microvascular response in 24 subjects with type 2 diabetes concluded: "Both types of irradiation stimulated microcirculation at the local and systemic levels through a mechanism of enhancement of endothelium-dependent and endothelium-independent vasodilation, in which nitric oxide plays a major role." [8]
  • A 2020 study investigating patient-specific response to the ability of PBM to increase blood flow concluded: "We demonstrated that PBM induces arteriolar vasodilation that results in both immediate and long-lasting increased capillary flow and tissue perfusion in healthy individuals." [9] Specifically, "Near-infrared PBM was found to induce a 27% increase in microcirculatory flow that increased to 54% during the 20-minute follow-up period” [10]


In Conclusion - Red and Infrared Light Therapy for Good Circulation and Microcirculation

Red/Infrared Light Therapy can effectively and easily increase circulation and microcirculation, plus accelerate your body’s own innate healing processes.  Red Light and Infrared Light Therapy can bring you, your family, and/or your patients a lifetime of improved health! If you are a chiropractor, physical therapist, medical doctor, acupuncturist, or podiatrist, consider adding Red Light/Infrared Therapy to your treatment menu.  One Red Light/Infrared Therapy system can result in better patient outcomes and make a big difference in your clinic! Contact Energia Medical at 860-707-4220  or via email  to learn more about Red Light/Infrared Therapy systems from Energia Medical.

 

Citations

[1] https://www.webmd.com/dvt/ss/slideshow-dvt-improve-circulation. p. 1.

[2] Tibiri E, Lorenzo A, Oliveira GMM. Microcirculation and Cardiovascular Diseases. Arq Bras Cardiol. 2018 Aug;111(2):120-121. doi: 10.5935/abc.20180149. PMID: 30183978; PMCID: PMC6122906, pps. 120-121.

[3] https://www.webmd.com/dvt/ss/slideshow-dvt-improve-circulation, pps. 4-14.

[4] Hamblin MR. Mechanisms and applications of the anti-inflammatory effects of photobiomodulation.AIMS Biophys. 2017;4(3):337-361. doi:10.3934/biophy.2017.3.337, p.1.

[5] Borsa PA, Larkin KA, True JM. Does phototherapy enhance skeletal muscle contractile function and postexercise recovery? A systematic review. J Athl Train. 2013 Jan-Feb;48(1):57-67. doi: 10.4085/1062-6050-48.1.12. PMID: 23672326; PMCID: PMC3554033. P. 57.

[6] Chung, Hoon, et al. The Nuts and Bolts of Low-level Laser (Light) Therapy. Ann Biomed Eng. 2012 February; 40(2): 516-533. doi:10.1007/s10439-011-0454-7, p. 5 of NIH Public Access version.

[7] Ibid., p. 6.

[8] Samoilova KA, Zhevago NA, Menshutina MA, Grigorieva NB. Role of nitric oxide in the visible light-induced rapid increase of human skin microcirculation at the local and systemic level: I. diabetic patients. Photomed Laser Surg. 2008 Oct;26(5):433-42. doi: 10.1089/pho.2007.2197. PMID: 18922086, Abstract.

[9] Gavish L, Hoffer O, Rabin N, Halak M, Shkilevich S, Shayovitz Y, Weizman G, Haim O, Gavish B, Gertz SD, Ovadia-Blechman Z. Microcirculatory Response to Photobiomodulation-Why Some Respond and Others Do Not: A Randomized Controlled Study. Lasers Surg Med. 2020 Nov;52(9):863-872. doi: 10.1002/lsm.23225. Epub 2020 Feb 17. PMID: 32064652, Abstract.

[10] Ibid.

Image Credit: &lt;ahref="https://www.freepik.com/free-vector/gradient-circulatory-system-infographic_10877929.htm#query=circulation&amp;position=1&amp;from_view=search&amp;track=sph">Freepik&lt;/a>

]]>Tue, 09 Jul 2024 11:00:00 -0400<![CDATA[Light Therapy for Minor Sprains and Injuries]]>https://www.energiamedical.com/blogs/post/light-therapy-for-minor-sprains-and-injuries

Light Therapy, also known as red light therapy, is known for relaxing and relieving muscle pain/spasms, joint aches, and stiffness related to arthritis while increasing local blood circulation. [1] This treatment stimulates and soothes aching muscles or joints of one’s body and improves its wellness. Light Therapy works by penetrating the skin and is absorbed by cells to trigger photobiomodulation (PBM) mechanisms, including the release of nitric oxide.


Besides, Light Therapy works reasonably well for minor sprains and injuries. It does not cause harm or increase heat/temperature in treated tissues, leading to a change in the tissue architecture. [2] When infrared light is combined with red light in one pad, then only the red light can be seen. It means that infrared light wavelength effuses its energy with more than 800 nm, which the human eye cannot see, reducing pain and increasing the blood flow motion. [3,4]


Light Therapy Affects Different Body Pains Positively


Muscle Sprain

Muscle sprain is one of the ailments that Light Therapy reduces pretty quickly. It’s caused by stretching/tearing muscle tissue connecting muscle to bone. The pain usually occurs in the lower back and at the back of the thighs.


Light Therapy heals or relieves this pain by penetrating light beneath the skin to reach muscle or aching joints. In effect, it helps cells absorb the light power and become more active. [4, 5]


Tennis Elbow

Tennis elbow is another type of pain that disturbs people at a high rate. It is commonly referred to as irritating the forearm muscle tissue to the elbow. It is caused by repetitive wrist and arm movements. [3]


Multiple mechanisms have been proposed to treat tennis elbow as a minor injury or sprain. But, pad therapy has been recognized as one of the best mechanisms to treat tennis elbow. It is because this treatment method relieves the pain by directing the light to areas that are injured without damaging the tissues. Also, Light Therapy promotes nitric oxide (NO) release as a photodissociation of NO from CCO, which subsequently increases the rate of ATP production and promotes vasodilation. [2,4,5]


Low Back Pain

Additionally, Light Therapy treats and relieves low back pain with the same mechanism as a minor sprain or injury. Low back pain is a painful condition affecting the back and lower part of the spine. It is caused by injury sprain or strain. Some common causes of low back pain include improper lifting, poor posture, lack of regular exercise, arthritis, etc.


Light Therapy reaches the muscles, nerves, and other tissues. It stimulates the regeneration and repair of injured tissues, decreasing pain. It also increases blood flow to different body parts, making it possible for oxygen and nutrients to reach the cells, enabling them to function appropriately. [4, 5, 6]


Muscle Spasms

Muscle spasms are among the types of discomfort treated by Light Therapy.  Muscle spasms are involuntary contractions of muscles that are temporary, not harmful, but painful. This muscle cramp is commonly caused by overuse of strength, fatigue, low magnesium, or low potassium. They can occur in any body part, but they often affect the abdomen, thighs, hands/arms, and feet. Light Therapy’s role is with pain relief, increasing blood motion while stimulating cell regeneration. The device assists the mitochondria in muscle cells to accomplish their respiration cycle, resulting is less fatigue. [4, 5]

Knee Pain

Lastly, Light Therapy relieves discomfort in various body parts, such as the knee. Knee pain may result from sitting on the knees for a long time, walking, bending, lifting, and standing. Those at risk of experiencing knee pain more often are athletes who run or play games with high levels of force on the knee.


Also, knee pain can be an outcome of aging, affecting the elderly with a more significant percentage of joint discomfort. But Light Therapy provides the appropriate pain relief for conditions including strained/sprained ligaments, tendonitis, arthritis, or cartilage tears. It operates by targeting the cellular origins of knee joint pain. [5, 7]

            

Conclusion

The reason why Light Therapy should be used for the above types of pain is that it offers painless remedies to individuals. Competitive athletes and weekend warriors benefit too. People can get back to their daily activities or players back to the game and perform at their prior level.


These light therapeutic remedies are advantageous because treatments are safe and can be used to treat multiple body areas. It heals the pain of the upper or lower back, feet, hip, or shoulder, resulting from sitting for long.  It’s equally essential to note that muscle, tennis elbow, knee pain, and other joint problems can impact both young and older adults.


If you would like to learn more about Light Therapy and its benefits, call Rob at 860-707-4220 or email Rob.


References:

How Red Light Can Help Athlete Body Recover and Versatile Pain Relief. January 18, 2018.

https://ledtechnologies.com

Hsin J and Western J, Treating Sport-Related Injury and Pain with Light Therapy. Pract Pain Manag. 2006;6(7)

https://www.practicalpainmanagement.com

Mayo Clinic, Different Pain Treatment. 1998 - 2022

https://www.mayoclinic.org

Hopkins J, Knee Pain, and Problems.

https://www.hopkinsmedicine.org

Velger L, Benefits of having your therapy systems. 2021;2(25)

https://healthlightllc.com

Laser Ther. 2016 March 31;25(1): 35-42

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC48468

Asthma C, Author manuscript; available in PMC 2020 July 13.  Laser Light Therapy in Inflammatory, Musculoskeletal, and Autoimmune Diseases.  19(8): 37. doi:10.1007/s11882-019-0869-z


Image Credit: &lt;ahref="https://www.freepik.com/free-photo/young-sportswoman-experiencing-pain-her-leg-while-having-sports-training-nature_25855574.htm#query=sprain&amp;position=1&amp;from_view=search&amp;track=sph">Image by Drazen Zigic&lt;/a> on Freepik
]]>Tue, 25 Jun 2024 12:00:00 -0400<![CDATA[The Role of LED Light Therapy In Optimizing Nitric Oxide Levels]]>https://www.energiamedical.com/blogs/post/the-role-of-led-light-therapy-in-optimizing-nitric-oxide-levels

Commonly called the ‘miracle molecule’, Nitric Oxide (NO) is a major signaling compound made by the body. As its production plays a key role in major cellular processes, regulating NO levels in the body could be the key to addressing various pathologies.

The discoveries surrounding the importance of NO resulted in a Nobel Prize for Physiology and Medicine for three US scientists—which led the medical community to recognize the compound for its various medical benefits. This article discusses the significance of NO in the human body and how can photobiomodulation through LEDs help increase NO levels. 


What is Nitric Oxide?

Nitric Oxide (NO) is an important compound in the human body that performs various physiological processes: It acts as a neurotransmitter, helps with cellular respiration, and adjusts cellular defenses (cell survival or death). Depleted or reduced NO levels can lead to various complications, such as hypertension.


Where is it Produced?

Most of the cells in the body produce NO, but it is largely produced by the endothelial cells, which line the blood vessels, and red blood cells, particularly from the mitochondria, as a result of ATP (adenosine triphosphate) synthesis. NO is a short-lived compound, which means that almost immediately after its production, it oxidizes to a stable form. 

Since NO is produced in the blood vessel lining, the endothelium, it helps to expand the vessels and regulates blood circulation. It is continuously produced in the endothelium and regulates blood pressure and normal blood homeostasis.


Why do We Need Nitric Oxide?

Our body needs NO to perform a variety of functions in the immune system, cardiovascular system, and nervous system. Here are some physiological actions of NO.


Effects on the Cardiovascular Health

Produced by the endothelial cells, NO can help mediate vasodilation of the blood vessels, preventing the blood cells from sticking to the endothelium, inhibiting the buildup of plaque, and increasing blood flow. Thus, optimal levels of NO improve heart health, regulate blood pressure and carotid artery blood flow, and prevent the stiffness of the arteries.

I

nduces Vasodilation

Since NO stimulates relaxation, it mediates the vasodilatory action by increasing blood flow and maintenance of blood pressure. Vasodilation also results in reduced inflammation and pain, so NO has anti-inflammatory and anti-pain effects too.


Regulates the Immune System

Since NO helps in cell signaling, it can prepare the body to react to foreign invaders. NO induces an effective response to infection, as it is produced by the macrophages to obliterate harmful bacteria. It acts as a vasodilator, cytotoxic mediator, and myocardial depressant.


Why do we Need to Monitor NO Levels?

The production of Nitric Oxide starts to drop by 20% every 10 years starting in your 30s. There are various factors (except age) that influence the decline of NO production, such as poor nutrition, oxidative stress, diabetes, and smoking. Anyone who is trying to maintain heart health and normal blood pressure has low energy, diabetes, or vascular dysfunction needs to monitor their NO levels. You might start looking for ways to optimize NO production if you are over 30.


How to Increase Nitric Oxide Levels

Reduced NO levels are often understood as related to vascular diseases. You can increase NO levels by consuming specific food groups or supplements. However, the most effective and risk-free method is LED Light Therapy.


LED Light Therapy for Nitric Oxide Production

Photobiomodulation or light therapy is a process where exposure to LED lights results in initiating several cellular processes that lead to enhanced ATP production, cellular regeneration, and tissue growth. Here is the mechanism of light therapy:

  • Light from a source initiates the production of NO from the endothelium and red blood cells
  • Nitric oxide causes localized vasodilation
  • Vasodilation promotes blood flow
  • NO also stimulates enhanced ATP production

The effects can last well after the therapy session is completed due to the continuous blood flow to the area, resulting in an uninterrupted incursion of red blood cells and the production of NO. You can use FDA cleared LED light pads that are proven to improve blood circulation and relieve pain.


Light Therapy can be used to increase blood circulation, relax muscles, and manage pain and stiffness due to arthritis.

You or your patients can benefit from increased NO production in several ways. Check out Energia Medical’s collection of LED pads. These come in a variety of sizes and can be used on any part of the body. These are FDA cleared and have no known side effects.


Contact Rob at 860-707-4220 to discuss light therapy or email Rob.

Citations

Smith, O. Nobel Prize for NO research. Nat Med 4, 1215 (1998). https://doi.org/10.1038/31821215 (1998). https://doi.org/10.1038/3182

Moncada S, Higgs EA. The discovery of nitric oxide and its role in vascular biology. Br J Pharmacol. 2006 Jan;147 Suppl 1(Suppl 1):S193-201. doi: 10.1038/sj.bjp.0706458. PMID: 16402104; PMCID: PMC1760731.

Luiking, Y. C., Engelen, M. P., & Deutz, N. E. (2010). Regulation of nitric oxide production in health and disease. Current opinion in clinical nutrition and metabolic care, 13(1), 97–104. https://doi.org/10.1097/MCO.0b013e328332f99d

Bauer V, Sotníková R. Nitric oxide--the endothelium-derived relaxing factor and its role in endothelial functions. Gen Physiol Biophys. 2010 Dec;29(4):319-40. PMID: 21156995.

Tschudi MR, Lüscher TF. Stickstoffmonoxid: Das endogene Nitrat im Kreislauf . Herz. 1996 Jun;21 Suppl 1:50-60. German. PMID: 8767925.

Akanji, M. A., Adeyanju, A. A., Rotimi, D., & Adeyemi, O. S. (2020, June 24). Nitric oxide balance in health and diseases: Implications for new treatment strategies. The Open Biochemistry Journal. https://openbiochemistryjournal.com/VOLUME/14/PAGE/25/FULLTEXT/

Keszler, A., Lindemer, B., Weihrauch, D., Jones, D., Hogg, N., & Lohr, N. L. (2017). Red/near infrared light stimulates release of an endothelium dependent vasodilator and rescues vascular dysfunction in a diabetes model. Free radical biology & medicine, 113, 157–164. https://doi.org/10.1016/j.freeradbiomed.2017.09.012

Karu TI, Pyatibrat LV, Afanasyeva NI. Cellular effects of low power laser therapy can be mediated by nitric oxide. Lasers Surg Med. 2005 Apr;36(4):307-14. doi: 10.1002/lsm.20148. PMID: 15739174.

]]>Tue, 06 Feb 2024 13:00:00 -0500<![CDATA[Combine Red Light/Infrared Therapy With Foods That Boost Nitric Oxide For Optimum Support]]>https://www.energiamedical.com/blogs/post/combine-red-light-infrared-therapy-with-foods-that-boost-nitric-oxide-for-optimum-support


If you want to get the most benefit from your Red Light/Infrared Therapy sessions, here’s a little secret: consume foods that promote the generation of nitric oxide.  For when you consume nitric oxide-promoting foods, combined with the nitric oxide released naturally within your red blood cells by your Red Light/Infrared Therapy sessions, you are therapeutically modulating nitric oxide bioactivity — and maximizing the benefits produced by your therapy sessions for the best possible therapeutic outcomes for yourself!

What is Nitric Oxide (NO)?

Nitric oxide has been called the “miracle molecule” and described as “the body’s natural vasodilator” for its beneficial effects on circulation and blood pressure. The nitric oxide (NO) molecule is gaseous, intracellular and intercellular, produced endogenously within your body through the oxidation of L-arginine in the endothelial cells which line the blood vessels in the inner layer of the arteries. “NO is a short-lived diatomic signaling molecule that exerts multiple effects on kidney, cardiovascular and metabolic functions, including modulation of renal autoregulation, tubular fluid and electrolyte transport, vascular tone, blood pressure, platelet aggregation, immune cell activation, insulin-glucose homeostasis and mitochondrial function.”  Scientists have discovered that NO also affects the liver, the eyes, and the gastrointestinal and nervous systems.

The Important Role of NO

In 2012, a scientific study stated that, “Nitric oxide (NO) has led a revolution in physiology and pharmacology research during the last two decades.” Although first identified as an endothelium-derived relaxing factor (EDRF) in connection with the vascular system, “Over the following years, however, the focus on NO research rapidly expanded from the vascular system to its role in immunity and inflammation, the nervous system, pregnancy, aging, and cell death.”  “…NO has emerged as a fundamental signaling device regulating virtually every critical cellular function, as well as a potent mediator of cellular damage in a wide range of conditions.”

Dangers of Compromised NO Production

Because NO plays such a vital role in the body, “Insufficient production of NO (for example, during older age and in various disease conditions) can adversely impact health and physical performance.”  “Reduced NO bioactivity due to compromised NO generation or increased metabolism has been associated with aging and kidney, cardiovascular and metabolic disorders, which are often coupled with increased generation of ROS leading to oxidative stress.”  And oxidative stress can be very damaging, as many healthcare professionals believe that it is the common denominator behind hundreds of diseases, plus the aging process itself.  Since NO is so crucial to good health, the ability of Red Light Therapy to locally release NO is extremely valuable!

Foods that Increase Nitric Oxide

NO can be boosted within the body by consuming nitrate-rich foods.  Green leafy vegetables such as arugula (the highest known source of nitrates), spinach, Swiss chard, parsley, and celery elevate NO levels. Other NO-enhancing foods are walnuts (high in L-arginine which converts into NO), watermelons (high in the amino acid L-citrulline, which converts into L-arginine and then into NO), pomegranates, cranberries, hot chili peppers, onions, garlic, raw cacao powder, dark chocolate, and beets — beet greens, beet chips, and beetroot juice.   And citrus fruits such as lemons, oranges, and grapefruits contain high amounts of Vitamin C, which raises levels of NO synthase (NOS) enzymes that convert L-arginine into NO, making citrus helpful to NO production.

Red Light/Infrared Therapy Releases NO

Scientific research proves that Red Light Therapy releases NO. How?  Photons of light emitted by the Red Light and Infrared Light Therapy pads are readily absorbed through the skin, penetrating deeply into tissues. Upon absorption, light is converted into signals that induce a wide range of beneficial biochemical processes in cells that stimulate and aid the body’s innate healing processes. During a Red Light/Infrared Therapy session, NO is a beneficial chemical released from blood vessels lining the endothelium. NO causes vasodilation, which significantly improves blood flow and circulation in the local area where therapy pads are placed. And, increased circulation helps to decrease inflammation and reduce pain.

In Conclusion – Try Red Light/Infrared Therapy

NO plays a vital role in a many key functions throughout the body, especially in promoting vasodilation and increased blood flow. Using Red Light and Infrared Light Therapy is a simple, easy, and dependable way to release NO so that blood, oxygen, and nutrients can flow optimally for pain relief and healing support. If you are looking to repair or enhance your health (and/or relieve pain and restore function) Red Light/Infrared Therapy can help.


And if you are a chiropractor, physical therapist, acupuncturist, or podiatrist, consider adding Red Light/Infrared Therapy to your treatment menu.  One Red Light/Infrared Therapy system can bring your patients years of improved health!  


Contact Rob Berman at Energia Medical at 860-707-4220 or via email Rob to learn more about Red Light/Infrared Therapy systems from Energia Medical.

Citations

Carlström M. Nitric oxide signalling in kidney regulation and cardiometabolic health. Nat Rev Nephrol. 2021 Sep;17(9):575-590. doi: 10.1038/s41581-021-00429-z. Epub 2021 Jun 1. PMID: 34075241; PMCID: PMC8169406, p. 575.

Bescós R, Sureda A, Tur JA, Pons A. The effect of nitric-oxide-related supplements on human performance. Sports Med. 2012 Feb 1;42(2):99-117. doi: 10.2165/11596860-000000000-00000. PMID: 22260513, Abstract.

Sobrevia L, Ooi L, Ryan S, Steinert JR. Nitric Oxide: A Regulator of Cellular Function in Health and Disease. Oxid Med Cell Longev. 2016;2016:9782346. doi: 10.1155/2016/9782346. Epub 2015 Dec 21. PMID: 26798429; PMCID: PMC4699049, p. 1.

Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 2007 Jan;87(1):315-424. doi: 10.1152/physrev.00029.2006. PMID: 17237348; PMCID: PMC2248324, Abstract.

Jones AM, Thompson C, Wylie LJ, Vanhatalo A. Dietary Nitrate and Physical Performance. Annu Rev Nutr. 2018 Aug 21;38:303-328. doi: 10.1146/annurev-nutr-082117-051622. PMID: 30130468, Abstract.

Carlström M. Nitric oxide signalling in kidney regulation and cardiometabolic health. Nat Rev Nephrol. 2021 Sep;17(9):575-590. doi: 10.1038/s41581-021-00429-z. Epub 2021 Jun 1. PMID: 34075241; PMCID: PMC8169406, p. 587.

]]>Tue, 23 Jan 2024 13:00:00 -0500<![CDATA[Does Light Therapy Work for Pain Management?]]>https://www.energiamedical.com/blogs/post/does-light-therapy-work-for-pain-management


Photobiomodulation, or Light Therapy, is a medical procedure where infrared or near-infrared light is used for neural stimulation, wound healing, and pain management and relief.


The process uses the power of LED lights to initiate biological responses that result in accelerated cell regeneration and tissue growth. This helps in managing pain, muscle soreness, and inflammation. Several clinical trials have demonstrated that a certain wavelength of light can speed up wound healing and decrease pain and inflammation.


LED Light Therapy is a well-known method of pain management today. This article discusses the

mechanism of Light Therapy and what the literature says about the effectiveness of this procedure in managing pain. 

How Does Light Therapy Work?

Red light can penetrate deep into the skin and initiate neural simulation. When the body part with pain is exposed to light, photoreceptive cells initiate metabolic events, which start a chain of several processes in the body on the cellular level. Infrared light stimulates the production of ATP (Adenosine Triphosphate) – the source of energy for cells.

Light energy also stimulates the production of nitric oxide, a substance that helps relax arteries, reduces oxidative stress, and assists and regulates blood pressure. Increased blood flood due to nitric oxide allows oxygen and nutrients to reach and heal the cells, resulting in lesser pain or soreness. 

What Pains Can be Treated with Light Therapy? 

As Light Therapy provides a targeted method of pain relief, it is proven to treat many types of pain, whether acute or chronic. It can be used on almost any part of the body to treat various types of pain.

Chronic Or Acute Pain 

Acute pain can lead to chronic pain and develop a series of health issues, including a general feeling of unwellness, sleeping problems, fatigue, high blood pressure, and fatigue. 20.3% of Americans are estimated to live with chronic pain.  

This means that 1 out of 5 adults experiences pain. Light Therapy can be used to treat acute or chronic pain without any major side effects. It heals tissues and results in an increased range of motion and improved functionality in patients with chronic pain.

Arthritis Pain

Light Therapy has been known to relieve pain and stiffness associated with various types of arthritis. Several studies prove the efficacy of Laser Therapy in treating arthritis pain. One study reveals that it can relieve up to 70% of pain and disability in patients with arthritis, resulting in improved activity.

Chronic Low Back Pain 

Research has shown a significant decrease in chronic low back pain with the use of LED Light Therapy in a placebo-controlled trial. It also shows that the pain can decrease by 50% without any side effects or risks of thermal injury.

Red Light Therapy is being used by medical practitioners and chiropractors to treat various kinds of pain, including:

  • Post-operative pain 
  • Joint and neck pain
  • Muscle soreness and pain 
  • Carpal Tunnel Syndrome 
  • Sprain, strain, and tendinitis 
  • Plantar Fasciitis 

How is Light Therapy Used?

Light Therapy is used via pads that emit infrared light. These tools are portable and fairly easy to use. They are also available in a variety of sizes and shapes for different body parts. You can get specialized pads for feet, legs, and calves or go for straight pads for other areas of the body such as the neck, shoulder, back, and thighs. 

Is Light Therapy Effective? 

Research shows that Light Therapy kickstarts neural stimulation and can help with pain management, healing, and neural regeneration. Several studies argue that photobiomodulation must become a crucial part of mainstream medicine due to its clinical applications in cellular mechanisms. LED Light Therapy is a better alternative to pain management than medication, as medicines carry side effects, and the body might become immune to them over some time. 

Are There Any Risks?

The use of Light Therapy for pain management and control was cleared by the FDA in 2002. There are no serious side effects to Light Therapy. Light Therapy is a much safer way to treat pain with little to no side effects. 

Conclusion 

Light Therapy is proven to stimulate healing, increase tissue regeneration, and reduce pain and inflammation. Studies have shown that this method of pain management is highly effective and free of any side effects and risks. 


Need a Light Therapy tool? Check out our collection of LED pads here and reap the benefits of risk-free pain management.  Call Rob Berman at 860-707-4220 or email Rob to discuss light therapy.

Citations 

Tsai, S. R., & Hamblin, M. R. (2017). Biological effects and medical applications of infrared radiation. Journal of photochemistry and photobiology. B, Biology, 170, 197–207. https://doi.org/10.1016/j.jphotobiol.2017.04.014

Searing, L. (2018, October 19). The Big Number: 50 million adults experience chronic pain. Retrieved June 8, 2022, from https://www.washingtonpost.com/national/health-science/the-big-number-50-million-adults-experience-chronic-pain/2018/10/19/30831828-d2e0-11e8-83d6-291fcead2ab1_story.html

Brosseau L, Welch V, Wells G, Tugwell P, de Bie R, Gam A, Harman K, Shea B, Morin M. Low level laser therapy for osteoarthritis and rheumatoid arthritis: a metaanalysis. J Rheumatol. 2000 Aug;27(8):1961-9. PMID: 10955339.

Gale, G. D., Rothbart, P. J., & Li, Y. (2006). Infrared therapy for chronic low back

pain: a randomized, controlled trial. Pain research & management, 11(3), 193–196. https://doi.org/10.1155/2006/876920

Karu T. (2013). Is it time to consider photobiomodulation as a drug equivalent?. Photomedicine and laser surgery, 31(5), 189–191. https://doi.org/10.1089/pho.2013.3510

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